Request iPSC cell lines
Use iPSC cell lines and organoids to model pediatric kidney disease, discover developmental mechanisms, rebuild kidneys or reengineer nephron segments, and screen for new drug treatments for kidney injury or failure.
Learn more about the cell lines and how to make a request.
Summary of iPSC lines being distributed
no. | Gene | Reporter | Targeting approach | Purpose | Parental line | Target validation | Genome integrity |
---|---|---|---|---|---|---|---|
1 | Control | NA | NA | Parental | BJFF6 | Y | Y |
2 | Control | NA | NA | Parental | AN1 | Y | Y |
3 | Control | NA | NA | Parental | WTC11 | Y | Y |
4 | RET:AAVS1 | tdT:GCaMP6f | 5′, T2A | Collecting duct progenitors, UB:calcium sensor | WTC11 | Y | Y |
5 | WNT9B | mCerulean3 | 3′, T2A | UB stalk | BJFF6 | Y | Y |
6 | CA2 | E2 Crimson | 3′, T2A | Intercalated cells | BJFF6 | Y | Y |
7 | AQP2 | EGFP | 3′, T2A | Principal cells | BJFF6 | Y | Y |
8 | UPK3A | mCerulean3 | 5′, T2A | Ureter/bladder epithelium | BJFF6 | Y | Y |
9 | HCN3 | membranetdT | 3′, T2A | Pacemaker cells | BJFF6 | Y | Y |
10 | SIX2 | EGFP | 3′, T2A | nephron progenitors | CRL-2429 | Y | Y |
11 | CITED1 | mCherry | 3, T2A | nephron progenitors | CRL-2429 | Y | Y |
12 | GATA3 | mCherry | 5′, T2A | collecting duct | CRL-2429 | Y | Y |
13 | CUBN | EGFP | 5′, polyA | proximal tubule | CRL-2429 | Y | Y |
14 | MAFB | mTagBFP2 | 5′, polyA | podocytes | CRL-2429 | Y | Y |
15 | SIX2/ CITED1 | EGFP/ mCherry | As above | nephron progenitors | CRL-2429 | Y | Y |
16 | GATA3/ MAFB | mCherry/ mTagFBP2 | As above | collecting duct and podocytes | CRL-2429 | Y | Y |
17 | GAPDH | EGFPloxP mCherry | 3′, T2A | Lineage tracing tool | CRL-2429 | Y | Y |
18 | GAPDH/ SIX2 | EGFPloxP mCherry/ Cre | 3′, T2A 3, T2A | lineage tracing of nephron progenitors | CRL-2429 | Y | Y |
19 | GATA3/ CUBN/ MAFB | mCherry/ EGFP/ mTagBFP2 | As above | collecting duct, proximal tubule and podocytes | CRL-2429 | Y | Y |
20 | |||||||
21 | GAPDH/ SIX2 | EGFPloxP mCherry/ CreERT2 | 3′, T2A 3, T2A | Lineage tracing of nephron progenitors | CRL-2429 | Y | Y |