Project 2

Project 2 will investigate the role of a new genetic driver of focal segmental glomerulosclerosis (FSGS).  Here single cell datasets, as in Project 1, will be generated at time points approximating the human postnatal development in control mice (for cross-species comparisons) and mouse model of FSGS (to find similarities in gene regulatory circuits with human FSGS).

Chart demonstrating Project 2 methodologies and outcomes.
Project 2 methodologies and outcomes.

Aim 1: Define cellular diversity, gene expression and the epigenetic landscape across the mouse kidney pediatric lifespan at timepoints relevant to kidney function and disease.

Aim 2: Determine cell states, expression signatures, pathways and gene regulatory mechanisms in a model of FSGS.

Principal Investigator